Coordinate regulation of EGFR/Akt signaling by miR-7 in HNC cells.

<p>Schematic representation of molecules in the EGFR/Akt signaling pathway that are inhibited by miR-7 in HNC. IPA software was used to map common miR-7-downregulated genes (shown in green) in FaDu and HN5 cells onto the canonical PI3K/Akt pathway. The density of shading represents the fold-change downregulation of a gene by miR-7. Blue circles indicate that a gene is a predicted or validated target of miR-7 by IPA analysis. Several genes belonging to the PI3K/Akt pathway that were downregulated by miR-7 in HN5 cells only are shaded in light blue.