Schematic representation of the genomic organization and alternative splicing of sea bass caspase-1.

<p>The exons are represented by boxes (E1-E8) and introns by a solid line (introns larger than 800 bp are represented by an interrupted solid line). Coding and untranslated regions are indicated by white and shaded boxes, respectively. Nucleotide numbers are given above the boxes. Caspase-1 domains and cleavage sites are schematically represented on top of each transcript. ATG: starting codon; QACRG: caspase-1 pentapeptide active-site motif; TGA/TAA: stop codon.