<p>All metrics were made following a 4 hour fasting period. The number of islets per pancreas is that collected for each mouse following pancreatic collagenase digestion and manual hand-picking as described <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003107#pgen.1003107-Keller1" target="_blank">[24]</a>.</p
Temporal changes in non-B cell populations were determined during the period of B cell hyperplasia i...
(A) Blood glucose levels during the 24 weeks of NCD or HFD feeding (mean data collected from 3 indep...
<p><b>A–B)</b> Non-fasting and fasting states of Sox17-paLOF and control mice at 1.5 years of age sh...
<p>The glycaemia of non-fasted mice (20 NOD females, 14 NOD-RIPN females, 16 NOD males, and 30 NOD-R...
<p>Mean ± SEM (n = 5–6).</p><p><sup>a</sup> Five weeks of age.</p><p><sup>b</sup> Ten weeks of age.<...
<p>A. Representative islets from B6 (left) and WSB (right) mice fed the chow diet. Insulin is staine...
<p>Representative images of age-dependent islet morphology at 5 (A), 12 (B), 24 (C), and 34 (D) week...
To characterise changes in pancreatic beta cell mass during the development of diabetes in untreated...
AIM: To characterise changes in pancreatic beta cell mass during the development of diabetes in untr...
Hereditary predisposition to diet-induced type 2 diabetes has not yet been fully elucidated. We rece...
Hereditary predisposition to diet-induced type 2 diabetes has not yet been fully elucidated. We rece...
<p>(A) Blood glucose levels (mg/dl) in fasted and ad-lib fed TG mice and their control littermates a...
<p>At day 130 after diabetes induction, pancreatic islets were observed (A) and quantified (B) in se...
<p>Male control and DJ-1 KO mice at 12–13 weeks of age were treated with 40 mg STZ/kg body weight on...
<p>The age (in weeks, wk) at which the mice entered the study is also reported as median±SD for isle...
Temporal changes in non-B cell populations were determined during the period of B cell hyperplasia i...
(A) Blood glucose levels during the 24 weeks of NCD or HFD feeding (mean data collected from 3 indep...
<p><b>A–B)</b> Non-fasting and fasting states of Sox17-paLOF and control mice at 1.5 years of age sh...
<p>The glycaemia of non-fasted mice (20 NOD females, 14 NOD-RIPN females, 16 NOD males, and 30 NOD-R...
<p>Mean ± SEM (n = 5–6).</p><p><sup>a</sup> Five weeks of age.</p><p><sup>b</sup> Ten weeks of age.<...
<p>A. Representative islets from B6 (left) and WSB (right) mice fed the chow diet. Insulin is staine...
<p>Representative images of age-dependent islet morphology at 5 (A), 12 (B), 24 (C), and 34 (D) week...
To characterise changes in pancreatic beta cell mass during the development of diabetes in untreated...
AIM: To characterise changes in pancreatic beta cell mass during the development of diabetes in untr...
Hereditary predisposition to diet-induced type 2 diabetes has not yet been fully elucidated. We rece...
Hereditary predisposition to diet-induced type 2 diabetes has not yet been fully elucidated. We rece...
<p>(A) Blood glucose levels (mg/dl) in fasted and ad-lib fed TG mice and their control littermates a...
<p>At day 130 after diabetes induction, pancreatic islets were observed (A) and quantified (B) in se...
<p>Male control and DJ-1 KO mice at 12–13 weeks of age were treated with 40 mg STZ/kg body weight on...
<p>The age (in weeks, wk) at which the mice entered the study is also reported as median±SD for isle...
Temporal changes in non-B cell populations were determined during the period of B cell hyperplasia i...
(A) Blood glucose levels during the 24 weeks of NCD or HFD feeding (mean data collected from 3 indep...
<p><b>A–B)</b> Non-fasting and fasting states of Sox17-paLOF and control mice at 1.5 years of age sh...