CCN5 KO mice exhibit mild type 2 diabetes.

(A) Blood glucose levels during the 24 weeks of NCD or HFD feeding (mean data collected from 3 independent experimental sets, n = 6–12 per group for each experimental set). (B) Fasting blood glucose levels in each group after 16 h of nocturnal fasting (mean data collected from 3 independent experimental sets, n = 6–12 per group for each experimental set). (C) Plasma adiponectin levels in each group (n = 4 for NCD group, n = 6 for HFD group). (D) ITT and GTT after 11 weeks of NCD or HFD feeding (n = 8–9 per group for each group). Plasma insulin levels after 12 weeks of NCD or HFD feeding (n = 7 per group). (E) ITT and GTT after 23 weeks old NCD or HFD feeding (mean data collected from 3 independent experimental sets, n = 6–8 per group for each experimental set). Plasma insulin levels after 24 weeks of NCD or HFD feeding (n = 7–8 per group). Data are presented as mean ± SD. *ppvs. WT.