Model validation using the steady state labeling distribution and dynamic human platelet results in [43].

<p>All labeled species are plotted separately with the number of attached atoms indicated by symbols. Measured data points from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002795#pcbi.1002795-Dawis1" target="_blank">[43]</a> are filled; Calculated points from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002795#pcbi.1002795-Dawis1" target="_blank">[43]</a> are unfilled; Lines represent simulations performed in this work. Subplot A shows the labeling distribution found at isotopic steady state as the is ranged from zero to 100% . The steady state points are identical to those predicted in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002795#pcbi.1002795-Dawis1" target="_blank">[43]</a>. Subplot B is a fit to the dynamic human platelet data in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002795#pcbi.1002795-Dawis1" target="_blank">[43]</a> (37 C, 32.3% .). The model in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002795#pcbi.1002795-Dawis1" target="_blank">[43]</a> is reproduced by setting the CK flux equal to zero and assuming all reactions are unidirectional. Note that the results of our simulation match with the simulation results in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002795#pcbi.1002795-Dawis1" target="_blank">[43]</a>. The parameters and from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002795#pcbi.1002795-Dawis1" target="_blank">[43]</a> were used to find the ATP pool (), and Pi pool ().