Residues involved in hydrogen bonds.

<p>The residues (labeled) of the SH2 domain that form hydrogen bonds with at least one of the 12 peptidomimetics are shown. The top figure shows a cartoon representation of the SH2 domain and the bottom figure shows a surface representation. The surface coloring shows the Coulombic electrostatic potential in different regions of the surface of the SH2 domain. The potential ranges from positive (in blue) to negative (in red). Note that a hydrogen bond is ignored if it is present in less than 50% of the conformations in the 10 ns molecular dynamics trajectory.