The electrostatic potential on the surface of the average conformation of the WT and H1047R p110α.

<p>The images depict membrane interaction areas of the WT (A) and H1047R mutant (B) first cluster representatives. The surface has been colored with a color scale from −7 eV to 7 eV, with red representing negative charge, white neutral and blue positive. The charge value corresponds to the solvent accessible surface of the protein, namely 1.4 Å far from the surface. These structures were derived from a cluster analysis including all the Cα carbon with a cutoff of 1.7 Å.