Lifespan of <i>BubR1</i><sup>+/GTTA</sup> is reduced.
- Tobias Wijshake (107900)
- Liviu A. Malureanu (107904)
- Darren J. Baker (107908)
- Karthik B. Jeganathan (107910)
- Bart van de Sluis (107913)
- Jan M. van Deursen (107916)
Publication date
December 2012
DOIAbstract
<p>Kaplan-Meier overall survival curves. Asterisks denote significance compared to wildtype mice using a log-rank test: **<i>P<0.01 and ***P<0.001</i>. The maximum lifespan was significantly decreased in <i>BubR1</i><sup>+/GTTA</sup> compared to wildtype (<i>P</i> = 0.0008; two-sided Wang/Allison test referring to the ratio of mice alive per genotype at the 90<sup>th</sup> percentile survival point) <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003138#pgen.1003138-Wang3" target="_blank">[70]</a>.</p
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