A. Disruption of the RIIβ subunit of Protein Kinase A increases lifespan in male mice on the C57BL/6 background.

<p>A. Both the median and maximum lifespans were significantly increased in mutant males compared to WT littermates. The median lifespan was increased from 884 days to 1005 days (p = 0.006 as determined by the log rank test) and the maximum lifespan (defined here as 80% deaths) was increased from 941 days to 1073 days (p = 0.004 as determined by the Wang-Allison test). B. There was no difference in either median or maximum lifespan in female genotypes.