<p>a) Shown are the seven ligands used in the computational studies. Sequences of only the EGF like domains of each ligand were used in the alignment. “*” represent 100% conservation while “.” and “:” represent partial sequence conservation.</p
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Accurate alignments of sequences are needed for many types of analyses. Aligned sequences might be t...
<p>White arrows indicate residues interacting with the IGF1-R, grey arrows indicate residues interac...
<p>There is a 48% amino acid identity of the entire subunit sequences. Within the ligand-binding dom...
<p>A multiple sequence alignment (Clustal Omega algorithm, <a href="http://www.ebi.ac.uk/Tools/msa/c...
<p>Mature ligand and receptor/co-receptor ecto domains were compared. Identities were calculated rel...
<p>(<b>A</b>) Graphical representation of sequence conservation and co-evolution in the E7C domain, ...
<p>The energy decomposition values for Arg41 vary for each ligand. GBSA values are depicted as solid...
<p>A The subdomains I, II, III and IV of both receptors are colored pink, orange, cyan and purple, r...
<p>(<b>A</b>) Graphical representation of sequence conservation and co-evolution in the E7N domain o...
<p>The residue-based betweenness profiles of the active EGFR dimer are shown for EGFR-WT (A, B) and ...
<p>The alignment is represented using the WebLogo 3 program <a href="http://www.ploscompbiol.org/art...
grantor: University of TorontoTo take full advantage of the current wealth of protein sequ...
<p>The degrees of conservation as well as the consensus between the amino acid sequences have been a...
<p>Dynamics-based analysis of structural stability in the active asymmetric dimers of EGFR-WT (A, B)...
<p>Conserved amino acid sequences are indicated by pink boxes for the Y-segment; blue boxes for the ...
Accurate alignments of sequences are needed for many types of analyses. Aligned sequences might be t...
<p>White arrows indicate residues interacting with the IGF1-R, grey arrows indicate residues interac...
<p>There is a 48% amino acid identity of the entire subunit sequences. Within the ligand-binding dom...
<p>A multiple sequence alignment (Clustal Omega algorithm, <a href="http://www.ebi.ac.uk/Tools/msa/c...
<p>Mature ligand and receptor/co-receptor ecto domains were compared. Identities were calculated rel...
<p>(<b>A</b>) Graphical representation of sequence conservation and co-evolution in the E7C domain, ...
<p>The energy decomposition values for Arg41 vary for each ligand. GBSA values are depicted as solid...
<p>A The subdomains I, II, III and IV of both receptors are colored pink, orange, cyan and purple, r...
<p>(<b>A</b>) Graphical representation of sequence conservation and co-evolution in the E7N domain o...
<p>The residue-based betweenness profiles of the active EGFR dimer are shown for EGFR-WT (A, B) and ...
<p>The alignment is represented using the WebLogo 3 program <a href="http://www.ploscompbiol.org/art...
grantor: University of TorontoTo take full advantage of the current wealth of protein sequ...
<p>The degrees of conservation as well as the consensus between the amino acid sequences have been a...
<p>Dynamics-based analysis of structural stability in the active asymmetric dimers of EGFR-WT (A, B)...
<p>Conserved amino acid sequences are indicated by pink boxes for the Y-segment; blue boxes for the ...
Accurate alignments of sequences are needed for many types of analyses. Aligned sequences might be t...
<p>White arrows indicate residues interacting with the IGF1-R, grey arrows indicate residues interac...
<p>There is a 48% amino acid identity of the entire subunit sequences. Within the ligand-binding dom...
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