<p>(<b>A</b>) Graphical representation of sequence conservation and co-evolution in the E7C domain, obtained from the alignment of 219 PV E7 sequences. Sequence numbering originates in the HPV16 E7 protein. The secondary structure of the E7C domain is depicted above the sequence. Highly conserved positions are marked by letters. These correspond to surface residues (S, orange), residues involved in the monomer hydrophobic core (M, blue), the dimerization interface (D, light blue) and residues involved in zinc binding (Z, red). Pairs of coevolving residues are indicated as filled triangles, open squares and open triangles, respectively. The locations of the known functional motifs are shown above the logos as boxes. The PDZ motif occurs at t...
Intrinsic disorder is abundant in viral genomes and provides conformational plasticity to its protei...
(A) HPV16 E6 structure (PDB file 4GIZ) showing the amino-terminal zinc-structured domain in green, c...
<p>The predicted glycosylation sites were marked with star underneath the alignment. Conserved histi...
<p>(<b>A</b>) Graphical representation of sequence conservation and co-evolution in the E7N domain o...
In the present work, we have used the papillomavirus E7 oncoprotein to pursue structure-function and...
In the present work, we have used the papillomavirus E7 oncoprotein to pursue structure-function and...
<p>(<b>A</b>) Left: Binding site for the p21 protein <a href="http://www.plosone.org/article/info:do...
<p>E7C is represented using the average NMR structure of the HPV45 E7C domain (PDB ID: 2F8B) and its...
<p>(<b>A</b>) Distribution of the number of cysteines in the cysteine-rich regions of individual E7C...
The HPV16 E7 oncoprotein is an extended dimer, with a stable and cooperative fold, but that displays...
<p>(A) Sequence conservation profile of the Hsp70 residues. The KL conservation score was calculated...
<p>The bottom layer includes simple units that can be assigned a conformational transition or biolog...
<p>A. Ribbon diagram of HPV16 E6 bound to the LXXLL motif from E6AP [<a href="http://www.plospathoge...
<p>Two NS5A-DI structures including (A) PDB-1ZH1 and (B) PDB-3FQM depicted below the NMR structure o...
Intrinsic disorder is abundant in viral genomes and provides conformational plasticity to its protei...
Intrinsic disorder is abundant in viral genomes and provides conformational plasticity to its protei...
(A) HPV16 E6 structure (PDB file 4GIZ) showing the amino-terminal zinc-structured domain in green, c...
<p>The predicted glycosylation sites were marked with star underneath the alignment. Conserved histi...
<p>(<b>A</b>) Graphical representation of sequence conservation and co-evolution in the E7N domain o...
In the present work, we have used the papillomavirus E7 oncoprotein to pursue structure-function and...
In the present work, we have used the papillomavirus E7 oncoprotein to pursue structure-function and...
<p>(<b>A</b>) Left: Binding site for the p21 protein <a href="http://www.plosone.org/article/info:do...
<p>E7C is represented using the average NMR structure of the HPV45 E7C domain (PDB ID: 2F8B) and its...
<p>(<b>A</b>) Distribution of the number of cysteines in the cysteine-rich regions of individual E7C...
The HPV16 E7 oncoprotein is an extended dimer, with a stable and cooperative fold, but that displays...
<p>(A) Sequence conservation profile of the Hsp70 residues. The KL conservation score was calculated...
<p>The bottom layer includes simple units that can be assigned a conformational transition or biolog...
<p>A. Ribbon diagram of HPV16 E6 bound to the LXXLL motif from E6AP [<a href="http://www.plospathoge...
<p>Two NS5A-DI structures including (A) PDB-1ZH1 and (B) PDB-3FQM depicted below the NMR structure o...
Intrinsic disorder is abundant in viral genomes and provides conformational plasticity to its protei...
Intrinsic disorder is abundant in viral genomes and provides conformational plasticity to its protei...
(A) HPV16 E6 structure (PDB file 4GIZ) showing the amino-terminal zinc-structured domain in green, c...
<p>The predicted glycosylation sites were marked with star underneath the alignment. Conserved histi...