Concentration-time profiles of AZI (A), LPS (B), total PCs (C), and KYN(D) after an i.p. LPS (0.8 mg/kg) and an i.g. AZI (100 mg/kg) in mice.

<p>(A): Closed squares and open squares indicated measured values in normal and LPS loading mice, respectively. Model fittings were presented as solid line for the normal mice and dash line for the LPS loading mice, respectively. (B): Closed squares and open squares indicated measured values in normal and AZI-treated mice, respectively. Model fittings were presented as solid line for normal mice and dash line for AZI-treated mice, respectively. (C) and (D): control mice were shown in closed squares and solid line. The model group was shown in closed circles and dot line. The regulative effect of AZI was shown in closed triangle with dash line. All observations were reported as Mean ±SD (n = 8) in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054981#pone-0054981-g002" target="_blank">Figure 2</a>.