Observed and predicted plasma concentration time profiles in mice after IV dosing of 75 nmol/kg containing 2.1 nCi ¹⁴C -labeled anti-IL17 as nanotracer.

A. Radioactivity levels (dpm mL-1) in mouse plasma determined by CRDS (triangles) and AMS (circles). For comparison, the radioactivity levels (A) of anti-IL17 in mouse plasma are given after a IV dose of 66 nmol/kg anti-IL17 containing 600 nCi 125I-labeled anti-IL17 (squares), for which the experimental details where reported elsewhere [11]. B and C Prediction corrected visual predictive check for the plasma concentration-time profiles of the anti-IL17 (all data). B. The solid black line represents the median prediction-corrected plasma concentration and the dark grey area represents a simulation-based 95% confidence interval for the median. C. The observed 2.5% (grey) and 97.5% (blue) percentiles are presented with dashed lines, and the 95% confidence intervals for the corresponding model predicted percentiles are shown as light dark grey and blue fields, respectively.