Model Comparison: Modeling Tumor Growth Inhibition by AZ968.

<p>A) Modeling of pharmacokinetic data after single i.p. dose of AZ968 at 10, 20 and 30 mg/kg. Data (symbols) was described with a 2 compartment model with dose-dependent elimination rate constant and central volume of distribution (model prediction in lines). B) Observed (symbols) and model predicted (lines) tumor volume using the lifespan model of tumor growth inhibition. Line style and color indicate unrestricted condition and oral treatment with AZ968 at 10, 20 and 30 mg/kg in mice xenograft. Symbols indicate control condition (black squares), 10 mg/kg AZ968 (black circles), 20 mg/kg (grey diamonds), and 30 mg/kg (grey triangles). Initial tumor volume was fixed at 180 mm³ as estimated from initial data points. C) Fitting of same AZ968 data using the Simeoni model.