Nox2KO BMMs have reduced cell displacement.

<p>WT and Nox2KO BMMs were seeded on plastic, CSF-1 deprived then stimulated with CSF-1 and imaged as described in material and Methods. A and B) cell tracks of WT and Nox2KO BMM respectively. The tracks have been re-set to co-ordinate (0,0). C and D) The number of cells reaching a set circular horizon was monitored and found to be significantly (p = 0.02) more in the WT than Nox2KO BMM following CSF-1 stimulation. (E and F) mean cell migration speed and mean persistence of direction were calculated from cell tracks above (see material and methods for details). Where blue bars represent CSF-1 starved and red bars represent CSF-1 stimulated cells ** = p<0.005.