Trends of the Treg frequency (upper panel), absolute number (middle panel) and activated Treg (lower panel), in the patients under investigation.

<p>Tregs were considered as those cells that were CD3+,CD4+, positive to FoxP3, highly positive (<i>i.e.</i>, bright) to CD25 and negative to CD127. Boxes indicate median values with 25th and 75th percentiles, whiskers show minimum and maximum.