BMD-mediated protection of RGC survival in ischemic injury.

<p>BMD or vehicle were administrated systemically for 4 weeks using osmotic pumps. (A–C) Brn3a whole-mount immunohistochemistry. High magnification showed representative images from the middle area of retinas. In comparison with normal control retina (A), vehicle-treated ischemic retina showed greater RGC loss (B). In contrast, BMD significantly increased RGC survival in ischemic retina (C). (D) The quantitative analysis of RGC loss. Values are mean ± SD (n = 6 retinas/group). *Significant at p<0.05 compared with non-ischemic contralateral control retina or vehicle-treated ischemic retina. BMD, brimonidine. Scale bar = 100 µm.