<p>Adult eye confocal optical projections from the <i>longGMRGal4</i> stock served as control (A), the starting <i>UAS::Parvin-GFP, longGMRGal4</i> genotype (B) and the recovered modifiers (C–L). The main suppressors of the modifier screen show morphology of the ommatidia that is reminiscent of the control: <i>UAS:Wech</i> (C), <i>UAS:PTEN</i> (E), <i>Df(3L)Exel6119</i> (G), <i>Df(3L)ED2</i> (I), and <i>UAS:IRXrp1</i> (K). The main enhancers of the screen are <i>Df(3R)e-GC3</i> (D), <i>UAS:IREip93F</i> (F), <i>UAS:IRmys</i> (H), <i>UAS:IRzasp52</i> (J), and <i>UAS:IRChd64</i> (L).</p
The eye primordium ((a) “E”, outlined) develops into the adult eye (b) through the action of a diffe...
(A-E) Micrographs of representative adult Drosophila eyes of the indicated genotypes. Shown to the r...
<p>GFP reporter expression driven by (A,C,E,G,I) GMR18D08>GFP and (B,D,F,H,J) GMR17E04>GFP in (A,B) ...
<p><b>Table key</b>. <b>E</b>: Enhancement; e: mild enhancement; <b>S</b>: Suppression; s: mild supp...
<p>(A) Stereomicroscope images of external eyes from control flies (<i>ey-Gal4/+</i>), flies express...
<p>(A-B) wild-type (A) third instar larval eye imaginal disc stained for Dlg (Blue), Elav (Red). (C-...
<p>(<b>A</b>) Rough eye phenotype (REP) used as a primary readout for screening. Compared to control...
<p>SEM was used to visualize adult eyes from the following genotypes: WT (A and F), <i>DmDyrk2<sup>−...
<p>(A) A correctly patterned heterozygous <i>GMR-GAL4/+</i> eye. (B) Mild mis-patterning manifested ...
<p>(A-B) wild-type (A) third instar larval eye imaginal disc stained for Dlg (Green), Elav (Red). (C...
<p>(A) The range of eye phenotypes observed in the assay. The <i>B</i><sup><i>S</i></sup> phenotype ...
<p>(A) Wild-type eyes show regularly structured ommatidia with interommatidial bristles. (B) The <i>...
<p>A) The wild-type adult eye displays a regular ommatidial lattice. B) The rough-eye phenotype gene...
<p>(A) Stereomicroscope images of adult fly eyes from controls (<i>ey-Gal4/+</i>), flies expressing ...
<p>The <i>Drosophila</i> eye consists of a hexagonal array of roughly 800 simple eyes called ommatid...
The eye primordium ((a) “E”, outlined) develops into the adult eye (b) through the action of a diffe...
(A-E) Micrographs of representative adult Drosophila eyes of the indicated genotypes. Shown to the r...
<p>GFP reporter expression driven by (A,C,E,G,I) GMR18D08>GFP and (B,D,F,H,J) GMR17E04>GFP in (A,B) ...
<p><b>Table key</b>. <b>E</b>: Enhancement; e: mild enhancement; <b>S</b>: Suppression; s: mild supp...
<p>(A) Stereomicroscope images of external eyes from control flies (<i>ey-Gal4/+</i>), flies express...
<p>(A-B) wild-type (A) third instar larval eye imaginal disc stained for Dlg (Blue), Elav (Red). (C-...
<p>(<b>A</b>) Rough eye phenotype (REP) used as a primary readout for screening. Compared to control...
<p>SEM was used to visualize adult eyes from the following genotypes: WT (A and F), <i>DmDyrk2<sup>−...
<p>(A) A correctly patterned heterozygous <i>GMR-GAL4/+</i> eye. (B) Mild mis-patterning manifested ...
<p>(A-B) wild-type (A) third instar larval eye imaginal disc stained for Dlg (Green), Elav (Red). (C...
<p>(A) The range of eye phenotypes observed in the assay. The <i>B</i><sup><i>S</i></sup> phenotype ...
<p>(A) Wild-type eyes show regularly structured ommatidia with interommatidial bristles. (B) The <i>...
<p>A) The wild-type adult eye displays a regular ommatidial lattice. B) The rough-eye phenotype gene...
<p>(A) Stereomicroscope images of adult fly eyes from controls (<i>ey-Gal4/+</i>), flies expressing ...
<p>The <i>Drosophila</i> eye consists of a hexagonal array of roughly 800 simple eyes called ommatid...
The eye primordium ((a) “E”, outlined) develops into the adult eye (b) through the action of a diffe...
(A-E) Micrographs of representative adult Drosophila eyes of the indicated genotypes. Shown to the r...
<p>GFP reporter expression driven by (A,C,E,G,I) GMR18D08>GFP and (B,D,F,H,J) GMR17E04>GFP in (A,B) ...