Effects of treatment with MTX alone or with supplementary folinic acid (FA) for 6 weeks on adipocyte density and mRNA expression of PPARγ.

<p>H&E-stained sections of tibia from a control (A), MTX-treated (B) and MTX+FA treated rat (C). Treatment effects on adipocyte density within bone marrow area of secondary spongiosa (D), and mRNA expression of PPARg relative to Cyclophilin-A (E). Scale bar on panel C = 250 µm, which applies to A and B.