Schematic and graphs illustrating the experimental approach (A) and results (B–E) for animals treated with CORT followed by vehicle.

<p><b>A:</b> Experimental protocol for the CORT-first treatment regimen. Video-EEG was monitored continuously throughout the entire regimen, with each period corresponding to 1–2 weeks. Twenty-four hour EEG segments quantified for epileptiform activity are denoted by arrows. The color of each part of the timeline corresponds to the bar color in the graphs shown below. <b>B:</b> CORT treatment significantly increased the number of epileptiform events relative to the preceding baseline period (1^st base). The number of epileptiform events was also increased during subsequent periods (2^nd baseline, vehicle) relative to the first baseline. <b>C:</b> CORT treatment significantly increased the total duration of epileptiform events relative to the preceding baseline period. The total duration of epileptiform events was also increased during subsequent periods relative to the first baseline. **, p<0.01 vs. 1^st baseline; ***, p<0.001 vs. 1^st baseline. <b>D:</b> No significant effects of vehicle or CORT treatment on seizure frequency were found. <b>E:</b> Mean seizure duration was statistically equivalent among treatment groups and baseline periods. Bar graphs show means ± SEM.