The schematic representation of the study protocol and a representative electroencephalogram data.

<p>(<b>A</b>) Sixty days after the pilocarpine induction of status epilepticus (SE), continuous video EEG monitoring was started. After 7 days of baseline recording, levetiracetam (LEV) was administered intraperitoneally (15 mg/kg/day) for 7 days. After a washout period of 7 days, valproate (VPA) was given intraperitoneally (30 mg/kg/day) for 7 days. Behavioral tests were performed following a 7-day washout period starting after the last administration of an AED. After all behavioral tests were completed, mice were sacrificed, and a microRNA microarray was performed. Control group is not illustrated because it was only exposed to mehylscopolamine and did not received pilocarpine. (B) Representative electroencephalogram (EEG) traces of SRS. Abbreviations: AED: antiepileptic drug, d: days, SRS: spontaneous recurrent seizure, LS: levetiracetam sensitive, LRVS: levetiracetam resistant/valproate sensitive, MDR: multidrug resistant.