Early seizure dynamics differ with optogenetic manipulation.

<p>Cumulative line-length, or path-length, of the cortical EEG recording in control (red, N = 14, from sham and additional control groups) and experimental (blue, N = 16) rats from onset to 25 minutes into the seizure, reflect changes in power and frequency on the standardized scale (Y axis). Areas with shallow slopes indicate lower seizure activity, while steep slopes indicate increased amounts of seizure activity as measured by line-length. <b>A</b> and <b>B</b> show individual animal plots for cortex and hippocampus, respectively. <b>C</b> and <b>D</b> show mean path-length ± SEM (represented by line and shading) of the control and experimental animals in cortex and hippocampus, respectively. The gray shaded box designates the time points at which cumulative line-length was statistically different between control and experimental animals (non-parametric, cluster-based statistical test, p<0.05).