Increased frequency of cells recognizing HLA-E/BZLF1 by CD8^bright cells in a CD94-independent manner in MS-RR and MS-PP patients.

<p>Tetramer HLA-E/A2 binding to CD8 total (A), CD8^bright (C), and CD8^dim (E) and tetramer HLA-E/BZLF1 binding to CD8 total (B), CD8^bright (D), and CD8^dim (F) are all expressed as percentage binding within lymphogate. Binding is analysed in the presence or absence of anti-CD94 blocking antibody. Comparisons between presence and absence of anti-CD94 are done using paired T-test. Other comparisons are done using Mann-Whitney U-test. The symbols indicating different p values are: * p≤0.0001, ** p≤0.001, *** p≤0.005, **** p≤0.003, ***** p≤0.007, # p≤0.01, ## p≤0.02, ### p≤0.03, #### p≤0.04.