<p>A mutated residue generated by site-directed mutagenesis is marked in red.</p
<p>The conserved PPxY and Px[TS]AP motifs are highlighted in grey. Putative glycosylation sites are ...
<p>The sequence and relative location of the 18-mer peptides used in this work, derived from the HCV...
Maturation of hepatitis C virus (HCV) core protein requires cleavage by signal peptidase (SP) and si...
<p>The plots show data from sets of overlapping 10-mer peptides representing portions of the HCV pol...
<p>Cleavage sites were identified by assaying 3,001 overlapping 10-mer peptides covering the entire ...
Amino acid alignment of all our HCV sequences in comparison with the HCV prototype strain H77 indica...
<p>Over 2660 peptides were cleaved by NS3/4A and by thrombin and furin (controls). The cleavage data...
<p>(<b>genotype 1a; GenBank accession P26664</b>) <b>with the NS3/4A cleavage sites.</b> Non-structu...
<p>(<b>A</b>) Schematic of the HCV polyprotein with cleavage sites of the two proteases, NS2 and NS3...
<p>BEFV antigenic sites and RABV antigenic sites are indicated by arrows above the sequence. Functio...
<p>All putative phosphorylation sites are underlined. The different domains defined for the P protei...
Hepatitis C NS3/4A protease is a prime therapeutic target that is responsible for cleaving the viral...
<p>Previously defined regions of the protein are indicated by the shaded boxes. Numbers correspond t...
<p>(A) Sequence alignment of region 313–327 from several HCV strains/isolates. (B) Sequence alignmen...
<p>a) The native complex 1mi5. No residue clashes are observed between the TCR and the MHC-peptide. ...
<p>The conserved PPxY and Px[TS]AP motifs are highlighted in grey. Putative glycosylation sites are ...
<p>The sequence and relative location of the 18-mer peptides used in this work, derived from the HCV...
Maturation of hepatitis C virus (HCV) core protein requires cleavage by signal peptidase (SP) and si...
<p>The plots show data from sets of overlapping 10-mer peptides representing portions of the HCV pol...
<p>Cleavage sites were identified by assaying 3,001 overlapping 10-mer peptides covering the entire ...
Amino acid alignment of all our HCV sequences in comparison with the HCV prototype strain H77 indica...
<p>Over 2660 peptides were cleaved by NS3/4A and by thrombin and furin (controls). The cleavage data...
<p>(<b>genotype 1a; GenBank accession P26664</b>) <b>with the NS3/4A cleavage sites.</b> Non-structu...
<p>(<b>A</b>) Schematic of the HCV polyprotein with cleavage sites of the two proteases, NS2 and NS3...
<p>BEFV antigenic sites and RABV antigenic sites are indicated by arrows above the sequence. Functio...
<p>All putative phosphorylation sites are underlined. The different domains defined for the P protei...
Hepatitis C NS3/4A protease is a prime therapeutic target that is responsible for cleaving the viral...
<p>Previously defined regions of the protein are indicated by the shaded boxes. Numbers correspond t...
<p>(A) Sequence alignment of region 313–327 from several HCV strains/isolates. (B) Sequence alignmen...
<p>a) The native complex 1mi5. No residue clashes are observed between the TCR and the MHC-peptide. ...
<p>The conserved PPxY and Px[TS]AP motifs are highlighted in grey. Putative glycosylation sites are ...
<p>The sequence and relative location of the 18-mer peptides used in this work, derived from the HCV...
Maturation of hepatitis C virus (HCV) core protein requires cleavage by signal peptidase (SP) and si...
DOI
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