Changing the Vβ-Vα orientation of a TCR/MHC-peptide complex.

<p>a) The native complex 1mi5. No residue clashes are observed between the TCR and the MHC-peptide. b) The complex with the TCR placed in the Vβ-Vα orientation of another TCR structure. A single clash (black line) is identified between the Vβ domain and the MHC. c) The complex with the TCR placed in the VH-VL orientation of an antibody. Multiple residue clashes, shown by black lines, are found between the Vβ domain and the MHC.