Homologues of MCU in pathogenic fungi.

<p>(<b>A</b>) Predicted topology of MCU channels, with the putative pore loop indicated; (<b>B</b>) Multiple sequence alignment of the TMDs and putative pore loop regions of human MCU and fungal homologues, with the predicted TMDs of each protein underlined; (<b>C</b>) Phylogram showing the relationship between the sequences of fungal, animal and plant MCU homologues (<i>see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042404#s3" target="_blank">Methods</a></i>: based on 89 high confidence positions from a multiple sequence alignment; gamma shape parameter 2.969; proportion of invariant sites 0.04). Branch length scale bar and branch support values >0.5 are shown.