<p>Fluorescent photomicrographs of hippocampal sagittal sections are shown with AT8 (Red, A-F), Total Tau (Green, G-L), or merged with DAPI (M-R), for the following groups: control (A, C, E, G, I, K, M, O, Q) or DMSO-treated mice (B, D, F, H, J, L, N, P, R).</p
<p>Immunohistochemistry with phosphorylation site-specific antibodies reveals several AT8-positive n...
<p>MC-1-positive neurons and cellular processes were seen in the motor cortex (A and B), prepotic ar...
<p>Hemi brains from 8, 14, 25 and 34-mo-old EC-Tau mice was stained with Alexa647-labeled CP27 antib...
<p>Hippocampal protein extracts were separated by SDS-PAGE and levels of tau phosphorylation were de...
<p>Hippocampal protein extracts were separated by SDS-PAGE and levels of tau phosphorylation were de...
<p>Hippocampal protein extracts were separated by SDS-PAGE and levels of kinases were determined usi...
<p>Brain sections from rTg9191 mice of 24 months of age (B, F, J, N, R, V, Z), their age-matched non...
<p>(<b>A</b>) Immunohistochemistry (IHC) of coronal brain sections obtained from 17 months-old pR5 m...
<p>Phosphorylated tau (P-tau) was detected in the hippocampus and cortex of WT/Tg and KO/Tg mice bra...
<p>Top panels illustrate <i>p</i>-tau IR in the hippocampus of 9 month old (<b>A</b> vs <b>B)</b> an...
<p>Phosphorylated tau/total tau ratios were expressed as percentage of wild-type Sham values. Differ...
<p>(<b>A–J</b>) Detailed graphs of the cortex and hippocampus that show the age-dependent intracellu...
<p>(<b>A</b>) Representative western blots showing GSK3β, phosphorylated GSK-3 (pSer9-GSK3β), AKT, p...
NFT-like images are evident in experimental but not in control mice. Images are representative of N ...
We have exploited whole brain microscopy to map the progressive deposition of hyperphosphorylated ta...
<p>Immunohistochemistry with phosphorylation site-specific antibodies reveals several AT8-positive n...
<p>MC-1-positive neurons and cellular processes were seen in the motor cortex (A and B), prepotic ar...
<p>Hemi brains from 8, 14, 25 and 34-mo-old EC-Tau mice was stained with Alexa647-labeled CP27 antib...
<p>Hippocampal protein extracts were separated by SDS-PAGE and levels of tau phosphorylation were de...
<p>Hippocampal protein extracts were separated by SDS-PAGE and levels of tau phosphorylation were de...
<p>Hippocampal protein extracts were separated by SDS-PAGE and levels of kinases were determined usi...
<p>Brain sections from rTg9191 mice of 24 months of age (B, F, J, N, R, V, Z), their age-matched non...
<p>(<b>A</b>) Immunohistochemistry (IHC) of coronal brain sections obtained from 17 months-old pR5 m...
<p>Phosphorylated tau (P-tau) was detected in the hippocampus and cortex of WT/Tg and KO/Tg mice bra...
<p>Top panels illustrate <i>p</i>-tau IR in the hippocampus of 9 month old (<b>A</b> vs <b>B)</b> an...
<p>Phosphorylated tau/total tau ratios were expressed as percentage of wild-type Sham values. Differ...
<p>(<b>A–J</b>) Detailed graphs of the cortex and hippocampus that show the age-dependent intracellu...
<p>(<b>A</b>) Representative western blots showing GSK3β, phosphorylated GSK-3 (pSer9-GSK3β), AKT, p...
NFT-like images are evident in experimental but not in control mice. Images are representative of N ...
We have exploited whole brain microscopy to map the progressive deposition of hyperphosphorylated ta...
<p>Immunohistochemistry with phosphorylation site-specific antibodies reveals several AT8-positive n...
<p>MC-1-positive neurons and cellular processes were seen in the motor cortex (A and B), prepotic ar...
<p>Hemi brains from 8, 14, 25 and 34-mo-old EC-Tau mice was stained with Alexa647-labeled CP27 antib...