Stimulation of TNFα and IL1ß production by a 6mer HA oligosaccharide.
- Helene C. D. Østerholt (319812)
- Ingrid Dannevig (319813)
- Myra H. Wyckoff (319814)
- Jie Liao (41399)
- Yucel Akgul (319816)
- Mrithyunjay Ramgopal (319818)
- Dan S. Mija (319819)
- Naeun Cheong (319820)
- Christopher Longoria (319821)
- Mala Mahendroo (319823)
- Britt Nakstad (319825)
- Ola D. Saugstad (233265)
- Rashmin C. Savani (319828)
Publication date
February 2013
DOIAbstract
<p>RAW264.7 murine macrophages (1×10<sup>6</sup>) were stimulated with a 10 µg/ml of 6-mer HA oligosaccharide <i>in vitro</i>. Supernatant IL1ß and TNFα were measured using standard ELISA. HA6 significantly stimulated the expression of both IL1ß and TNFα in the macrophage cell line, thereby confirming that LMW HA can stimulate the expression of inflammatory cytokines in macrophages.</p
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