<p><b>a</b>) (<i>left</i>) peak somatic membrane potential as a function of stimulus strength in a non spiking single-compartmental model, with (<i>red</i> traces) or without <i>I<sub>h</sub></i> (<i>black</i> traces) and different values for the <i>K<sub>M</sub></i> peak conductance, <i>g<sub>KM</sub></i>; note the large depolarization with <i>g<sub>KM</sub></i> = 0; (<i>right</i>) same as in the <i>left</i> panel but using a spiking single-compartmental model; insets show somatic potential during a current clamp of 0.5 or 0.05 nA with or without <i>K<sub>M</sub></i>, respectively. <b>b</b>) peak somatic membrane potential as a function of stimulus strength using the full realistic morphology with (<i>red</i> traces) or without <i>I<sub>h<...
We have computationally explored the effect of quantitative variations in the extent of cell-to-cell...
<p>The maximum conductance of the h-type current and the mean of the input current (-700 pA) were r...
<p>The graphs show the membrane potential of the PG cell model in response to a depolarizing current...
<p><b>a</b>) (<i>left</i>) peak somatic membrane potential as a function of synaptic stimulation str...
<p>A. Application 1, demonstrating the uncoupling of [Ca<sup>2+</sup>]<sub>i</sub> and membrane pote...
A: Somatic membrane potential time courses according to the Almog model in response to 2-ms square-p...
<p><b>A.</b> Varying the rate of excitatory synaptic drive (<i>f</i><sub>exc</sub>) caused a depolar...
<p>A: Membrane potential distributions of GIF and r-matched IF neurons in response to the background...
<p>(<b><i>A</i></b>) The traces depict a sigmoidal reduction of G<sub>max,Kir</sub> from 0.2 nS to 0...
<p>(A) The left upper panel shows a plot of Ca<sup>2+</sup>-activated K<sup>+</sup> (<i>I</i><sub><i...
A: Almog- (top) and Hay-model (bottom) morphology color-coded according to distance from soma. Inset...
<p>The light stimulus (top) was identical to Fig. 5. The current traces from Fig. 5 are translated i...
<p>(A) The relation between somatic <i>I</i><sub>Na</sub>, <i>I</i><sub>K</sub>, <i>I</i><sub>SL</su...
<p>(A) Examples of firing responses of the model neuron with different maximal specific conductance ...
<p>Dynamics of the iGIF model (with parameters extracted from a typical Pyr neuron) responding to th...
We have computationally explored the effect of quantitative variations in the extent of cell-to-cell...
<p>The maximum conductance of the h-type current and the mean of the input current (-700 pA) were r...
<p>The graphs show the membrane potential of the PG cell model in response to a depolarizing current...
<p><b>a</b>) (<i>left</i>) peak somatic membrane potential as a function of synaptic stimulation str...
<p>A. Application 1, demonstrating the uncoupling of [Ca<sup>2+</sup>]<sub>i</sub> and membrane pote...
A: Somatic membrane potential time courses according to the Almog model in response to 2-ms square-p...
<p><b>A.</b> Varying the rate of excitatory synaptic drive (<i>f</i><sub>exc</sub>) caused a depolar...
<p>A: Membrane potential distributions of GIF and r-matched IF neurons in response to the background...
<p>(<b><i>A</i></b>) The traces depict a sigmoidal reduction of G<sub>max,Kir</sub> from 0.2 nS to 0...
<p>(A) The left upper panel shows a plot of Ca<sup>2+</sup>-activated K<sup>+</sup> (<i>I</i><sub><i...
A: Almog- (top) and Hay-model (bottom) morphology color-coded according to distance from soma. Inset...
<p>The light stimulus (top) was identical to Fig. 5. The current traces from Fig. 5 are translated i...
<p>(A) The relation between somatic <i>I</i><sub>Na</sub>, <i>I</i><sub>K</sub>, <i>I</i><sub>SL</su...
<p>(A) Examples of firing responses of the model neuron with different maximal specific conductance ...
<p>Dynamics of the iGIF model (with parameters extracted from a typical Pyr neuron) responding to th...
We have computationally explored the effect of quantitative variations in the extent of cell-to-cell...
<p>The maximum conductance of the h-type current and the mean of the input current (-700 pA) were r...
<p>The graphs show the membrane potential of the PG cell model in response to a depolarizing current...