The expression of IGF1 mRNA in the DG of WT and G93A mice subject to treadmill running (EX) or sedentary lifestyle (SED).

<p>(A) IGF1 mRNA hybridization signal in the DG of WT mice. (B) IGF1 mRNA hybridization signal in the DG of G93A mice. (C) There was no significant difference between WT-SED and G93-SED mice, n = 11–13 per group. (D).Exercising WT mice had a trend to increase expression of IGF1 mRNA in the DG by 12.0% vs WT-SED mice, † P = 0.064, n = 11–12 per group. (E) There was no significant difference in DG IGF1 mRNA expression between G93A-SED and G93A-EX mice, n = 9–13 per group. Data are means ± SEM. Red arrows indicated IGF1 mRNA hybridization signal in the DG.