<i>Abcb1a/b</i> (−/−) and <i>Abcg2</i> (−/−) mice display higher brain and blood THC levels compared to WT mice.

<p>Brain (A) and blood (B) THC concentrations in WT, <i>Abcb1a/b</i> (−/−) and <i>Abcg2</i> (−/−) mice at 0.5, 1, 2 and 3 h after acute administration of THC (mean ± SEM). <i>Abcb1a/b</i> (−/−) or <i>Abcg2</i> (−/−) compared to WT group at specific time-points * <i>P</i><0.05, ** <i>P</i><0.01, <i>Abcb1a/b</i> (−/−) compared to <i>Abcg2</i> (−/−), # <i>P</i><0.05. For WT mice n = 6 (0.5 h), n = 5 (1 h), n = 6 (2 h) and n = 5 (3 h). For <i>Abcb1a/b</i> (−/−) n = 6 (0.5 h), n = 5 (1 h), n = 6 (2 h) and n = 5 (3 h). For <i>Abcg2</i> (−/−) n = 6 (0.5 h), n = 5 (1 h), n = 5 (2 h) and n = 4 (3 h).