THC prevents MDMA-induced glial activation at both room and warm temperature.

<p>CD11b (a) and GFAP (b) staining quantification in mice housed at 21 and 26±1°C. Data are expressed as mean ± SEM of percentage of stained area (<i>n</i> = 3–7). ★★★ <i>p</i><0.001 when compared with vehicle-treated group. ☆☆☆ <i>p</i><0.001 when compared with MDMA-treated group. § <i>p</i><0.05, §§ <i>p</i><0.01, when compared with animals housed at 21±1°C (Tukey's test or one-way ANOVA).