Chronic Δ⁹-THC treatment and survival of mice given a secondary systemic challenge with <i>C. albicans</i>.

<p>Female c57BL/6 mice (n = 7/group) received vehicle or Δ⁹-THC at the indicated concentrations on days 1–4, 8–11 and 15–18. The mice were challenged with <i>C. albicans</i> (7.5×10⁴ yeast cells/mouse (ms), i.v.) on day 2 and again challenged with <i>C. albicans</i> (5×10⁵ yeast cells/ms, i.v.) on day 19. The mice were monitored daily for survival. Compared to the survival of vehicle treated mice, the p values are as follows: Δ⁹-THC 4 mg/kg (p = 0.28), Δ⁹-THC 8 mg/kg (p = 0.14), Δ⁹-THC 16 mg/kg (p = 0.06), Δ⁹-THC 32 mg/kg (p = 0.03) and Δ⁹-THC 64 mg/kg (p = 0.01). The data are representative of two experiments.