Effect of genetic background on survival in different mutant <i>SOD1</i> transgenic mouse lines.

<p>(A) Survival curves for C57BL/6 (B6) congenic <i>SOD1^G93A</i> transgenic female mice (B6_G93A F) (closed circle: n = 19) and FVB/N (FVB) congenic <i>SOD1^G93A</i> transgenic female mice (FVB_G93A F) (open square: n = 20). (B) Survival curves for B6 congenic <i>SOD1^G93A</i> transgenic male mice (B6_G93A M) (closed circle: n = 15) and FVB congenic <i>SOD1^G93A</i> transgenic male mice (FVB_G93A M) (open square: n = 17). (C) Survival curves for B6 congenic <i>SOD1^H46R</i> transgenic female mice (B6_H46R F) (closed circle: n = 31) and FVB congenic <i>SOD1^H46R</i> transgenic female mice (FVB_H46R F) (open square: n = 20). (D) Survival curves for B6 congenic <i>SOD1^H46R</i> transgenic male mice (B6_H46R M) (closed circle: n = 63) and FVB congenic <i>SOD1^H46R</i> transgenic male mice (FVB_H46R M) (open square: n = 27). Kaplan-Meier analysis with Log-rank (Mantel-Cox) test identifies significant differences in survival for mutant SOD1 transgenic lines between B6 and FVB backgrounds (<i>p</i><0.0001).