Effects of rs10052957 (Tth111l) and rs6190 (R23K) genotypes on GR mRNA expression.
- Duncan Sinclair (329606)
- Janice M. Fullerton (320844)
- Maree J. Webster (171539)
- Cynthia Shannon Weickert (105000)
Publication date
February 2013
DOIAbstract
<p>A) A significant main effect of rs10052957 genotype on GR-1B mRNA expression was identified (ANCOVA F(2, 81) = 5.32, <i>p</i><0.001), with significant decreases in GR-1B expression in individuals with CC genotype (n = 46) relative to those with TC genotype (n = 40; 18.4% decrease, <i>p</i><0.05) and TT genotype (n = 9; 31.8% decrease, <i>p</i><0.005). B) An effect of rs6190 genotype on GR-1C mRNA expression was also observed (Mann-Whitney U-test, z = 2.58, <i>p</i><0.01), with a 24.8% decrease in GG homozygotes (n = 91) relative to GA heterozygotes (n = 4). Error bars represent SEM. * <i>p</i><0.05, ** <i>p</i><0.005.</p
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