Effect of rs41423247 (Bcl1) genotype on GRα protein expression in the DLPFC.
- Duncan Sinclair (329606)
- Janice M. Fullerton (320844)
- Maree J. Webster (171539)
- Cynthia Shannon Weickert (105000)
Publication date
February 2013
DOIAbstract
<p>There were significant main effects of genotype on IR band 2 intensity (ANCOVA, F(2, 87) = 4.85, <i>p</i><0.05) and total IR bands 1–5 (ANOVA F(2, 86) = 3.28, <i>p</i><0.05). The abundance of IR band 2 (67 kDa GRα) was significantly decreased in rs41423247 GG homozygotes (n = 11; 26.5% decrease, <i>p</i><0.05) and GC heterozygotes (n = 43; 23.4% decrease, <i>p</i><0.01) relative to CC homozygotes (n = 41). The total GRα abundance (IR bands 1–5) was decreased (15.1%) in GC heterozygotes relative to CC homozygotes (<i>p</i><0.05). * p<0.05, ** p = 0.006.</p
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