Electrophysiological characterization of α7^L247T nAChRs expressed in <i>Xenopus</i> oocytes in response to acetylcholine.

<p>Bar charts illustrate responses (mean ± SEM) from α7^L247T nAChRs expressed in <i>Xenopus</i> oocytes in response to a maximal (30 µM) and <i>EC</i>₅₀ (0.4 µM) concentration of acetylcholine (A and B, respectively) at room temperature (RT; 21°C), higher temperature (37°C) and lower temperature (4°C). Data are means of 5–9 responses, each from a different oocyte, in which responses obtained at either 4°C or 37°C are normalized to responses obtained from the same oocyte at RT. C) Representative traces illustrating responses obtained at RT (upper trace) and 4°C (lower trace) from a single oocyte. D) Representative traces illustrating responses obtained at RT (upper trace) and 37°C (lower trace) from a single oocyte.