Protective effect of multiple-clade influenza vaccine in mice challenged with A/OT/SZ/097/03.

<p>Groups of mice (<i>n</i> = 10/group) were immunized i.n. with single H5N1 influenza split vaccines (3 µg HA per dose) and a trivalent vaccine that contained 1 µg HA per dose of each single vaccine in combination with adjuvant and challenged i.n. with 50LD₅₀ OT/SZ/097/03 virus suspension. Mice were monitored for weight change (A) and survival rates (B) throughout a 14-day observation period.