<p>Six-week-old female BALB/c mice (n = 6) were immunized twice with 10 ug of 3M2eC protein plus 2 ug of CT at 2 week intervals via i.n. or s.l., or with 10 ug of 3M2eC protein plus alum by i.d. or i.m.. They were challenged i.n. with 10 LD<sub>50</sub> of mouse adapted PR8 strain (H1N1) at 3 weeks (A and B), A/Aquatic Bird/Korea/W81/05 virus (H5N2) at 3 weeks (C and D) or A/Philippine/2/82 (H3N2) virus at 5 weeks (E and F) after the last immunization. Survival rate and the body weight loss were monitored daily after the challenge. The results are expressed as the means+S.D. for the group.</p
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
<p>Groups of mice were immunized according to the schedule, either i.n. or orally, with PBS, pgsA/<i...
<p>A–B: Protection against A/California/04/2009 virus challenge. Mice intramuscularly immunized with...
<p>The immunized mice were intranasally challenged with the reassortant RG2 (clade 2.1) or NIBRG23 (...
<p>Groups of mice (<i>n</i> = 10/group) were immunized i.n. with single H5N1 influenza split vaccine...
<p>Five-week-old female BALB/c mice (5 per group) were vaccinated with PBS, pgsA/<i>L. casei</i>, pg...
<p>(A–B) Groups of vaccinated mice and a mock control were intranasally challenged with a lethal dos...
<p>Mice (<i>n</i> = 4) were intranasally infected with a lethal dose of influenza virus mixed with i...
<p>Survival rates (A, C) and average body weight loss (B, D) of BALB/c (A, B) or C57BL/6 (C, D) mice...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
<p>Mice were immunized i.n. or s.l. with 3M2eC (10 ug) plus CT (2 ug) on days 0 and 14 and challenge...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
<p>Groups of mice were immunized according to the schedule, either i.n. or orally, with PBS, pgsA/<i...
<p>A–B: Protection against A/California/04/2009 virus challenge. Mice intramuscularly immunized with...
<p>The immunized mice were intranasally challenged with the reassortant RG2 (clade 2.1) or NIBRG23 (...
<p>Groups of mice (<i>n</i> = 10/group) were immunized i.n. with single H5N1 influenza split vaccine...
<p>Five-week-old female BALB/c mice (5 per group) were vaccinated with PBS, pgsA/<i>L. casei</i>, pg...
<p>(A–B) Groups of vaccinated mice and a mock control were intranasally challenged with a lethal dos...
<p>Mice (<i>n</i> = 4) were intranasally infected with a lethal dose of influenza virus mixed with i...
<p>Survival rates (A, C) and average body weight loss (B, D) of BALB/c (A, B) or C57BL/6 (C, D) mice...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
<p>Mice were immunized i.n. or s.l. with 3M2eC (10 ug) plus CT (2 ug) on days 0 and 14 and challenge...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
Sequential infection with antigenically distinct influenza viruses induces cross-protective immune r...
<p>Groups of mice were immunized according to the schedule, either i.n. or orally, with PBS, pgsA/<i...