<p>A wild-type mouse (W), an untreated Sandhoff mouse (S), and a Sandhoff mouse treated with the modified Hex B (S+E). Arrows indicate the peak of lyso-GM2.</p
<p>A: Levels of Aβ40 were significantly increased in the vehicle-treated Ts65Dn vs. 2N mice. JZL184-...
<p>A) Compounds 40 & 43 robustly increase activity of human purified GBA1 when added to mouse brain ...
<p>10% brain homogenates were prepared from the secondary passage mice (secondary ID #41–64) inocula...
<p>Lyso-GM2 levels in brain tissues (<b>A</b>) and plasma (B). Wild-type mice (W,♦), untreated Sandh...
<p>GM2 levels in brain tissues of wild-type mice (W,♦), untreated Sandhoff mice (S,▪), and Sandhoff ...
<p>Structure of lyso-GM2 (top) and its spectra obtained for the brain of a Sandhoff mouse (bottom).<...
To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM...
To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM...
<p>A) blank mouse brain extract, B) blank mouse brain extract spiked with ar-turmerone (AT) and inte...
<p>(A): IMS of GM1 d18∶1 from a mouse receiving a MCAO followed by 7 d reperfusion. ROIs were highli...
<p>(1) LG and HG: APP/PSN (Fig 5A) mice with 7 months of intervention; MG: APP/PSN (Fig 5B) mice wit...
(A) LacCer synthase activity was measured in brain homogenates from wild-type (wt) and B4galt5 and 6...
<p>The relative abundance of lyso-Gb3 analogues as to lyso-Gb3 in organs and plasma of the wild-type...
<p>(A): Sham-operated mice were sacrificed and their brains were removed, flash frozen and sectioned...
<p>Histology of the brains showing LFB staining (blue) and PAS staining (pink) in the corpus callosu...
<p>A: Levels of Aβ40 were significantly increased in the vehicle-treated Ts65Dn vs. 2N mice. JZL184-...
<p>A) Compounds 40 & 43 robustly increase activity of human purified GBA1 when added to mouse brain ...
<p>10% brain homogenates were prepared from the secondary passage mice (secondary ID #41–64) inocula...
<p>Lyso-GM2 levels in brain tissues (<b>A</b>) and plasma (B). Wild-type mice (W,♦), untreated Sandh...
<p>GM2 levels in brain tissues of wild-type mice (W,♦), untreated Sandhoff mice (S,▪), and Sandhoff ...
<p>Structure of lyso-GM2 (top) and its spectra obtained for the brain of a Sandhoff mouse (bottom).<...
To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM...
To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM...
<p>A) blank mouse brain extract, B) blank mouse brain extract spiked with ar-turmerone (AT) and inte...
<p>(A): IMS of GM1 d18∶1 from a mouse receiving a MCAO followed by 7 d reperfusion. ROIs were highli...
<p>(1) LG and HG: APP/PSN (Fig 5A) mice with 7 months of intervention; MG: APP/PSN (Fig 5B) mice wit...
(A) LacCer synthase activity was measured in brain homogenates from wild-type (wt) and B4galt5 and 6...
<p>The relative abundance of lyso-Gb3 analogues as to lyso-Gb3 in organs and plasma of the wild-type...
<p>(A): Sham-operated mice were sacrificed and their brains were removed, flash frozen and sectioned...
<p>Histology of the brains showing LFB staining (blue) and PAS staining (pink) in the corpus callosu...
<p>A: Levels of Aβ40 were significantly increased in the vehicle-treated Ts65Dn vs. 2N mice. JZL184-...
<p>A) Compounds 40 & 43 robustly increase activity of human purified GBA1 when added to mouse brain ...
<p>10% brain homogenates were prepared from the secondary passage mice (secondary ID #41–64) inocula...