<p>Lyso-GM2 levels in brain tissues (<b>A</b>) and plasma (B). Wild-type mice (W,♦), untreated Sandhoff mice (S,▪), and Sandhoff mice treated with the modified Hex B (S+E,▴). Each line indicates the mean±SD. *P<0.05 (<i>t</i>-test).</p
<p>Structure of lyso-GM2 (top) and its spectra obtained for the brain of a Sandhoff mouse (bottom).<...
<p>Wild-type mouse lines RIII and VM, inoculated with vCJD(BSE) and vCJD(transfusion) were assessed ...
<p><b>A.</b> Levels of Aβ in brain tissue were determined using monoclonal antibody 4G8 that recogni...
<p>GM2 levels in brain tissues of wild-type mice (W,♦), untreated Sandhoff mice (S,▪), and Sandhoff ...
<p>A wild-type mouse (W), an untreated Sandhoff mouse (S), and a Sandhoff mouse treated with the mod...
To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM...
To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM...
<p>The relative abundance of lyso-Gb3 analogues as to lyso-Gb3 in organs and plasma of the wild-type...
<div><p>Brain homogenates were treated with or without PK as indicated prior to SDS PAGE analysis.</...
<div><p>Brain homogenates from (A) clinically and pathologically positive 79A inoculated G2 or wild-...
<p>Seven-week old male mice had free access to regular chow or high fat diet or were allowed to have...
<p>A) Compounds 40 & 43 robustly increase activity of human purified GBA1 when added to mouse brain ...
<p>A: Levels of Aβ40 were significantly increased in the vehicle-treated Ts65Dn vs. 2N mice. JZL184-...
<p>(A): IMS of GM1 d18∶1 from a mouse receiving a MCAO followed by 7 d reperfusion. ROIs were highli...
Representative Western blot images and band intensities quantified by densitometry in 2- (2M), 8- (8...
<p>Structure of lyso-GM2 (top) and its spectra obtained for the brain of a Sandhoff mouse (bottom).<...
<p>Wild-type mouse lines RIII and VM, inoculated with vCJD(BSE) and vCJD(transfusion) were assessed ...
<p><b>A.</b> Levels of Aβ in brain tissue were determined using monoclonal antibody 4G8 that recogni...
<p>GM2 levels in brain tissues of wild-type mice (W,♦), untreated Sandhoff mice (S,▪), and Sandhoff ...
<p>A wild-type mouse (W), an untreated Sandhoff mouse (S), and a Sandhoff mouse treated with the mod...
To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM...
To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM...
<p>The relative abundance of lyso-Gb3 analogues as to lyso-Gb3 in organs and plasma of the wild-type...
<div><p>Brain homogenates were treated with or without PK as indicated prior to SDS PAGE analysis.</...
<div><p>Brain homogenates from (A) clinically and pathologically positive 79A inoculated G2 or wild-...
<p>Seven-week old male mice had free access to regular chow or high fat diet or were allowed to have...
<p>A) Compounds 40 & 43 robustly increase activity of human purified GBA1 when added to mouse brain ...
<p>A: Levels of Aβ40 were significantly increased in the vehicle-treated Ts65Dn vs. 2N mice. JZL184-...
<p>(A): IMS of GM1 d18∶1 from a mouse receiving a MCAO followed by 7 d reperfusion. ROIs were highli...
Representative Western blot images and band intensities quantified by densitometry in 2- (2M), 8- (8...
<p>Structure of lyso-GM2 (top) and its spectra obtained for the brain of a Sandhoff mouse (bottom).<...
<p>Wild-type mouse lines RIII and VM, inoculated with vCJD(BSE) and vCJD(transfusion) were assessed ...
<p><b>A.</b> Levels of Aβ in brain tissue were determined using monoclonal antibody 4G8 that recogni...