NMO-IgG localization to AQP4-expressing peripheral organs following intravenous administration.

<p>NMO-IgG or a control human IgG were injected intravenously in wild type and AQP4 knockout mice. After 24 hours, tissues were fixed and stained for AQP4 (green). NMO-IgG and control IgG were detected using a secondary anti-human antibody (red). Confocal fluorescence images shown of kidney (A), skeletal muscle (B), trachea (C) and stomach (D). Arrowheads indicate basolateral membrane of kidney collecting duct (A), skeletal muscle sarcolemma (B), basolateral membrane of tracheal surface epithelial cells (C), and basolateral membrane of gastric parietal cells (D). Data are representative of 3 mice per group.