<p>WT (A) and AQP4 knockout (B) brain sections were stained with a serum showing NMO IgG-like staining at low magnification. Inset (A) shows that the serum staining (green) is restricted to endothelial cells of the brain capillaries and not to astrocyte processes stained red by AQP4 antibodies. (B) Staining of AQP4−/− mouse endothelial cells of the serum under analysis. Magnification bar 10 µm.</p
Autoantibody neuromyelitis optica-IgG (NMO-IgG) recognizing aquaporin-4 (AQP4) is implicated as play...
AbstractNeuromyelitis optica (NMO), an autoimmune disease of the central nervous system, is characte...
<p>(A–C) AQP4 IHC signals in swollen end-feet of astrocytes around cerebral vessels in ipsilateral p...
<p>A. Confocal fluorescence images for studies as in <a href="http://www.plosone.org/article/info:do...
<p>Anti-AQP4 IgG (red) in NMO patient's serum targets AQP4 (green), which is expressed by transientl...
<p>The corresponding staining patterns (A, B, C, D; typical and atypical white matter staining), as ...
Recent advances in the field of neuromyelitis optica (NMO) research provided convincing evidence tha...
<p>NMO-IgG or a control human IgG were injected intravenously in wild type and AQP4 knockout mice. A...
<p>(A) Negative control without primary antibody gave negative result with no detectable AQP4 labeli...
The water channel aquaporin-4 (AQP4) is the target of the immunoglobulin G autoantibody (AQP4-IgG) i...
<p>(A) Rat control brain, AQP4 (red) is restricted to astrocytic endfeet contacting the blood vessel...
<p>(A) In human glioblastoma tissue AQP4 (red) shows an intensive staining whereas in primary cell c...
Neuromyelitis optica immunoglobulin G (NMO-IgG) binds the aquaporin-4 (AQP-4) water channel of astro...
<p>Bound IgG was visualized using secondary antibodies labeled with FITC (green). Cell nuclei, stain...
<p>Patients´serum shows extensive labeling of the granular layer of the cerebellum (A). Note the ret...
Autoantibody neuromyelitis optica-IgG (NMO-IgG) recognizing aquaporin-4 (AQP4) is implicated as play...
AbstractNeuromyelitis optica (NMO), an autoimmune disease of the central nervous system, is characte...
<p>(A–C) AQP4 IHC signals in swollen end-feet of astrocytes around cerebral vessels in ipsilateral p...
<p>A. Confocal fluorescence images for studies as in <a href="http://www.plosone.org/article/info:do...
<p>Anti-AQP4 IgG (red) in NMO patient's serum targets AQP4 (green), which is expressed by transientl...
<p>The corresponding staining patterns (A, B, C, D; typical and atypical white matter staining), as ...
Recent advances in the field of neuromyelitis optica (NMO) research provided convincing evidence tha...
<p>NMO-IgG or a control human IgG were injected intravenously in wild type and AQP4 knockout mice. A...
<p>(A) Negative control without primary antibody gave negative result with no detectable AQP4 labeli...
The water channel aquaporin-4 (AQP4) is the target of the immunoglobulin G autoantibody (AQP4-IgG) i...
<p>(A) Rat control brain, AQP4 (red) is restricted to astrocytic endfeet contacting the blood vessel...
<p>(A) In human glioblastoma tissue AQP4 (red) shows an intensive staining whereas in primary cell c...
Neuromyelitis optica immunoglobulin G (NMO-IgG) binds the aquaporin-4 (AQP-4) water channel of astro...
<p>Bound IgG was visualized using secondary antibodies labeled with FITC (green). Cell nuclei, stain...
<p>Patients´serum shows extensive labeling of the granular layer of the cerebellum (A). Note the ret...
Autoantibody neuromyelitis optica-IgG (NMO-IgG) recognizing aquaporin-4 (AQP4) is implicated as play...
AbstractNeuromyelitis optica (NMO), an autoimmune disease of the central nervous system, is characte...
<p>(A–C) AQP4 IHC signals in swollen end-feet of astrocytes around cerebral vessels in ipsilateral p...