Regulation of chemokine and chemokine receptor expression in adult NPCs by IFNγ and TNFα.

<p>(A) Selected representative gels of RT-PCR for chemokine (CXCL and CCL) and chemokine receptor (CXCR and CCR) expression in adult neurospheres under control (C) conditions or treated with 100 U/ml IFNγ (I), 100 U/ml TNFα (T) or IFNγ plus TNFα (I+T). (B–D) The relative expression level of each chemokine or receptor in response to addition of (B) IFNγ, (C) TNFα or (D) IFNγ plus TNFα was normalized by densitometric analysis to control expression levels for each chemokine or receptor and expressed as fold difference compared to control. Results show mean+/−SEM of at least n = 3 individual experiments; *<i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001.