Exposure to IH induces anxiety in mice.

<p>C57BL6/J mice exposed to IH spend significantly less time in the open arm of the elevated plus maze compared to RA C57BL6/J, or <i>gp91phox</i>^_<i>/Y</i> mice exposed to either RA or IH (<i>A</i>). A reduced number of closed-arm entries emerged in wild type mice exposed to IH (<i>B</i>). (C) Time spend in the Center Area was increased in wild type mice exposed to IH (n = 12/experimental group; *<i>P</i><0.05).