Uptake of soluble Aβ by wildtype and Tg2576 cortical neurons <i>in vitro</i>.

<p>Wildtype and Tg2576 cortical neurons were treated with 10 µM of monomeric Aβ_1-40, and immunostained for Aβ after 24 hours. In untreated Tg2576 neurons, Aβ was smoothly distributed throughout the cytoplasm and processes of all neurons (A). When Aβ_1-40 was applied to wildtype neurons, it was internalised and distributed in a punctate manner within the cytoplasm and processes (B). Notably, not all wildtype neurons internalised Aβ_1-40 (B). When Aβ_1-40 was applied to Tg2576 neurons, both smooth and punctately distributed Aβ was detected within neurons (C). scale bar = 25 µm.