Plots of all outcome measures within cortical (upper half) and subcortical (lower half) ROI's per group and time point.

<p>Control mice after <b><u>t</u></b>MCAO (solid black lines) and <i>anti-GPIb</i> treated mice (dashed red lines) showed significant group differences in the postischemic course of CBF (first column): sustained reperfusion in <i>anti-GPIb</i> treated mice vs. progression of hypoperfusion in controls, which was most marked in the cortex (Interaction GROUPxTIME; p = 0.00001). This effect of CBF was paralleled by a decrease in cortical and subcortical ADC in controls, but stable cortical ADC in <i>anti-GPIb</i> treated mice and less severe subcortical ADC decrease in <i>anti-GPIb</i> treated mice as compared to controls (second column). The third column (qT2) indicated severe increase in the cortical and subcortical T2 relaxation constant over time reflecting the demarcation of irreversible tissue damage for controls. In contrast, <i>anti-GPIb</i> treated mice exhibit stable T2 values in the cortex protected from infarction and in the subcortex exhibit only moderate increase in mean T2 as compared to control mice consistent with a lower group probability of infarction in this region. Probability of infarction (fourth column) by automated segmentation of individual animals is consistently lower for <i>anti-GPIb</i> treated mice, a finding most marked in the cortex.