Simulations of viral genomic diversification with a low frequency of multiple infections.

<p>The evolution of (A) viral diversity, <i>d_G</i>, (B) divergence, <i>d_S</i>, and (C) average fitness, <i>f</i>, with generations predicted by our simulations for different population sizes, <i>C</i>. Each cell is assumed to be infected with <i>M</i> virions drawn from a distribution based on a viral dynamics model (see text). Error bars represent standard deviations.