Bryostatin is non-toxic at its active concentration either alone or in combination with other anti-HIV compounds.

<p>Magi and Jurkat cells were treated with various therapeutic drugs (MF-Metformin (1 mM), Min-Minocycline (5 µg/ml and 10 µg/ml), Sim-Simvastatin (2.5 µM), and AZT (100 µM), S.Sali-Sodium salicylate (1 mM) either alone or in combination with bryostatin for 48 and 72 h and cell survival was determined using WST8/CCK8 cytotoxicity assay. (<b>A</b>) Survival of Magi cells after treatment with bryostatin and other drugs, (<b>B</b>) bryostatin in combination with other drugs. (<b>C</b>) Jurkat cell survival after treatment with bryostatin (25 ng/ml) and other drugs, (<b>D</b>) bryostatin in combination with other drugs. Each treatment was done in triplicate. (n = 2).