Bryostatin-1+JQ1-mediated HIV-1 reactivation is dependent on NF-κB and P-TEFb and independent from NFAT.
- Gilles Darcis (777607)
- Anna Kula (151641)
- Sophie Bouchat (777608)
- Koh Fujinaga (245282)
- Francis Corazza (777609)
- Amina Ait-Ammar (777610)
- Nadège Delacourt (777611)
- Adeline Melard (389677)
- Kabamba Kabeya (262465)
- Caroline Vanhulle (262476)
- Benoit Van Driessche (5664676)
- Jean-Stéphane Gatot (262470)
- Thomas Cherrier (262484)
- Luiz F. Pianowski (340559)
- Lucio Gama (139021)
- Christian Schwartz (179570)
- Jorge Vila (293026)
- Arsène Burny (77340)
- Nathan Clumeck (262491)
- Michel Moutschen (262488)
- Stéphane De Wit (262489)
- B. Matija Peterlin (13310)
- Christine Rouzioux (204733)
- Olivier Rohr (9127)
- Carine Van Lint (9121)
Publication date
July 2015
DOIAbstract
<p>The T-lymphoid J-Lat 9.2 (panel <b>A</b>) and monocytic THP89GFP (panel <b>B</b>) cell lines harbor latent HIV-1 provirus containing <i>gfp</i> gene. The cells were pre-treated with the indicated inhibitors for 2 hours and then either mock-treated or treated with the combination bryostatin-1 [10nM]+JQ1 [0.5μM]. At 24 hours post-treatment, cells were analyzed by flow cytometry to quantify the proportion of cells expressing GFP. Means and standard errors of the means from duplicate samples are indicated. One representative experiment from two is represented.</p
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